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Chemoselective reductive cross-coupling of 1,5-diene-3-ols with alkynes: a facile entry to stereodefined skipped trienes.


ABSTRACT: A convergent synthesis of highly substituted and stereodefined skipped polyenes is described from the reductive cross-coupling of substituted 1,5-diene-3-ols with alkynes. The control of site selectivity in functionalization of the substituted diene is a central feature of this complex fragment union reaction.

SUBMITTER: Diez PS 

PROVIDER: S-EPMC2912438 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature

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Chemoselective reductive cross-coupling of 1,5-diene-3-ols with alkynes: a facile entry to stereodefined skipped trienes.

Diez Peter S PS   Micalizio Glenn C GC  

Journal of the American Chemical Society 20100701 28


A convergent synthesis of highly substituted and stereodefined skipped polyenes is described from the reductive cross-coupling of substituted 1,5-diene-3-ols with alkynes. The control of site selectivity in functionalization of the substituted diene is a central feature of this complex fragment union reaction. ...[more]

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