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ABSTRACT:
SUBMITTER: Margutti S
PROVIDER: S-EPMC2915348 | biostudies-literature | 2007 Dec
REPOSITORIES: biostudies-literature
Acta crystallographica. Section E, Structure reports online 20071218 Pt 1
The crystal structure of the title compound, C(16)H(16)FN(2)O(2) (+)·I(-), was determined as part of a study of the biological activity of isoxazolone derivatives as p38 mitogen-activated protein kinase (MAPK) inhibitors. The X-ray crystal structure of 4-[4-(4-fluoro-phenyl)-2-methyl-5-oxo-2,5-dihydro-isoxazol-3-yl]-1-methyl-pyridinium iodide showed the presence of the regioisomer 4-[3-(4-fluoro-phenyl)-2-methyl-5-oxo-2,5-dihydro-isoxazol-4-yl]-1-methyl-pyridinium iodide. The synthesis of the fo ...[more]