Ontology highlight
ABSTRACT:
SUBMITTER: Oguchi Y
PROVIDER: S-EPMC2917589 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Nature chemical biology 20100314 4
The dimeric motor myosin V transports organelles along actin filament tracks over long distances in cells. Myosin V is a smart 'walker' that is able to swiftly adjust to variable 'road conditions' to continue its processive movement across dense cellular environments. Coordination between the two heads via intramolecular load modulates biochemical kinetics and ensures highly efficient unidirectional motion. However, little is known about how load-induced regulation of the processive stepping occ ...[more]