Ontology highlight
ABSTRACT:
SUBMITTER: O'Connell RM
PROVIDER: S-EPMC2922591 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
O'Connell Ryan M RM Chaudhuri Aadel A AA Rao Dinesh S DS Gibson William S J WS Balazs Alejandro B AB Baltimore David D
Proceedings of the National Academy of Sciences of the United States of America 20100726 32
The production of blood cells depends on a rare hematopoietic stem-cell (HSC) population, but the molecular mechanisms underlying HSC biology remain incompletely understood. Here, we identify a subset of microRNAs (miRNAs) that is enriched in HSCs compared with other bone-marrow cells. An in vivo gain-of-function screen found that three of these miRNAs conferred a competitive advantage to engrafting hematopoietic cells, whereas other HSC miRNAs attenuated production of blood cells. Overexpressio ...[more]