Ontology highlight
ABSTRACT:
SUBMITTER: Simon MD
PROVIDER: S-EPMC2932701 | biostudies-literature | 2007 Mar
REPOSITORIES: biostudies-literature
Simon Matthew D MD Chu Feixia F Racki Lisa R LR de la Cruz Cecile C CC Burlingame Alma L AL Panning Barbara B Narlikar Geeta J GJ Shokat Kevan M KM
Cell 20070301 5
Histone lysine residues can be mono-, di-, or trimethylated. These posttranslational modifications regulate the affinity of effector proteins and may also impact chromatin structure independent of their role as adaptors. In order to study histone lysine methylation, particularly in the context of chromatin, we have developed a chemical approach to install analogs of methyl lysine into recombinant proteins. This approach allows for the rapid generation of large quantities of histones in which the ...[more]