Ontology highlight
ABSTRACT:
SUBMITTER: Kim CH
PROVIDER: S-EPMC3783207 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Kim Chan Hyuk CH Kang Mingchao M Kim Hak Joong HJ Chatterjee Abhishek A Schultz Peter G PG
Angewandte Chemie (International ed. in English) 20120611 29
A novel post-translationally modified amino acid, crotonyllysine (Kcr), was genetically incorporated into proteins in bacterial and mammalian cells using an evolved pyrrolysyl-tRNA/synthetase-tRNA pair. The ability to produce histones with homogenous, site-specific Kcr modifications will be valuable in elucidating the biological role of this recently identified post-translational modification. ...[more]