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Site-specific incorporation of ?-N-crotonyllysine into histones.


ABSTRACT: A novel post-translationally modified amino acid, crotonyllysine (Kcr), was genetically incorporated into proteins in bacterial and mammalian cells using an evolved pyrrolysyl-tRNA/synthetase-tRNA pair. The ability to produce histones with homogenous, site-specific Kcr modifications will be valuable in elucidating the biological role of this recently identified post-translational modification.

SUBMITTER: Kim CH 

PROVIDER: S-EPMC3783207 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature

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Site-specific incorporation of ε-N-crotonyllysine into histones.

Kim Chan Hyuk CH   Kang Mingchao M   Kim Hak Joong HJ   Chatterjee Abhishek A   Schultz Peter G PG  

Angewandte Chemie (International ed. in English) 20120611 29


A novel post-translationally modified amino acid, crotonyllysine (Kcr), was genetically incorporated into proteins in bacterial and mammalian cells using an evolved pyrrolysyl-tRNA/synthetase-tRNA pair. The ability to produce histones with homogenous, site-specific Kcr modifications will be valuable in elucidating the biological role of this recently identified post-translational modification. ...[more]

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