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Melanoma targeting with the loco-regional chemotherapeutic, Melphalan: From cell death to immunotherapeutic efficacy.


ABSTRACT: All immunoregulatory chemotherapeutics are chiefly applied in a systemic setting for anticancer therapy. However, immune responses following loco-regional application of chemotherapy may differ from those after systemic application. We recently found that Melphalan, a prototypical loco-regionally applied chemotherapeutic agent, exhibits the ability to increase the immunogenicity of dying melanoma cells.

SUBMITTER: Dudek-Peric AM 

PROVIDER: S-EPMC4635703 | biostudies-other | 2015 Dec

REPOSITORIES: biostudies-other

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