Ontology highlight
ABSTRACT:
SUBMITTER: Xu X
PROVIDER: S-EPMC7007861 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Xu Xiaoou X Eshima Shizuka S Kato Shinichiro S Fisher David E DE Sakurai Hiroaki H Hayakawa Yoshihiro Y Yokoyama Satoru S
Molecular cancer therapeutics 20191119 2
Mutation of the oncogene BRAF is among the most common genetic alterations in melanoma. BRAF inhibitors alone or in combination with MEK inhibitors fail to eradicate the tumor in most patients due to combinations of intrinsic or acquired resistance. Therefore, novel strategies are needed to improve the therapeutic efficacy of BRAF inhibition. We demonstrated that dinaciclib has potent antimelanoma effects by inducing BAK-dependent apoptosis through MCL1 reduction. Contrary to dinaciclib, the inh ...[more]