Ontology highlight
ABSTRACT:
SUBMITTER: Benoist M
PROVIDER: S-EPMC3746201 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Benoist Marion M Palenzuela Rocío R Rozas Carlos C Rojas Patricio P Tortosa Elena E Morales Bernardo B González-Billault Christian C Ávila Jesús J Esteban José A JA
The EMBO journal 20130723 16
The microtubule-associated protein 1B (MAP1B) plays critical roles in neurite growth and synapse maturation during brain development. This protein is well expressed in the adult brain. However, its function in mature neurons remains unknown. We have used a genetically modified mouse model and shRNA techniques to assess the role of MAP1B at established synapses, bypassing MAP1B functions during neuronal development. Under these conditions, we found that MAP1B deficiency alters synaptic plasticity ...[more]