Ontology highlight
ABSTRACT:
SUBMITTER: Reichow SL
PROVIDER: S-EPMC2950906 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Reichow Steve L SL Korotkov Konstantin V KV Hol Wim G J WG Gonen Tamir T
Nature structural & molecular biology 20100919 10
The type II secretion system (T2SS) is a macromolecular complex spanning the inner and outer membranes of Gram-negative bacteria. Remarkably, the T2SS secretes folded proteins, including multimeric assemblies such as cholera toxin and heat-labile enterotoxin from Vibrio cholerae and enterotoxigenic Escherichia coli, respectively. The major outer membrane T2SS protein is the 'secretin' GspD. Cryo-EM reconstruction of the V. cholerae secretin at 19-Å resolution reveals a dodecameric structure remi ...[more]