Ontology highlight
ABSTRACT:
SUBMITTER: Reichow SL
PROVIDER: S-EPMC3225749 | biostudies-literature | 2011 May-Jun
REPOSITORIES: biostudies-literature
Reichow Steve L SL Korotkov Konstantin V KV Gonen Melissa M Sun Ji J Delarosa Jaclyn R JR Hol Wim G J WG Gonen Tamir T
Channels (Austin, Tex.) 20110501 3
The type II secretion system (T2SS) is a large macromolecular complex spanning the inner and outer membranes of many gram-negative bacteria. The T2SS is responsible for the secretion of virulence factors such as cholera toxin (CT) and heat-labile enterotoxin (LT) from Vibrio cholerae and enterotoxigenic Escherichia coli, respectively. CT and LT are closely related AB5 heterohexamers, composed of one A subunit and a B-pentamer. Both CT and LT are translocated, as folded protein complexes, from th ...[more]