Ontology highlight
ABSTRACT:
SUBMITTER: Niphakis MJ
PROVIDER: S-EPMC2953738 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
The Journal of organic chemistry 20101001 20
Six- and seven-membered cyclic enaminones can be prepared using common, environmentally benign reagents. Amino acids are used as synthetic precursors allowing diversification and the incorporation of chirality. The key reaction in this multistep process involves deprotection of Boc-amino ynones and subsequent treatment with methanolic K(2)CO(3) to induce cyclization. A β-amino elimination side reaction was identified in a few labile substrates that led to either loss of stereochemical purity or ...[more]