Ontology highlight
ABSTRACT:
SUBMITTER: Jacob Y
PROVIDER: S-EPMC2964344 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Jacob Yannick Y Stroud Hume H Leblanc Chantal C Feng Suhua S Zhuo Luting L Caro Elena E Hassel Christiane C Gutierrez Crisanto C Michaels Scott D SD Jacobsen Steven E SE
Nature 20100714 7309
Multiple pathways prevent DNA replication from occurring more than once per cell cycle. These pathways block re-replication by strictly controlling the activity of pre-replication complexes, which assemble at specific sites in the genome called origins. Here we show that mutations in the homologous histone 3 lysine 27 (H3K27) monomethyltransferases, ARABIDOPSIS TRITHORAX-RELATED PROTEIN5 (ATXR5) and ATXR6, lead to re-replication of specific genomic locations. Most of these locations correspond t ...[more]