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Homogeneous pd-catalyzed enantioselective decarboxylative protonation.

ABSTRACT: General homogeneous conditions for the palladium-catalyzed synthesis of carbonyl compounds with tertiary carbon stereocenters at the alpha-position are reported. The highly reactive catalyst tolerates a variety of substrate substitution and functionality, and generates enantioenriched cyclic ketones from racemic allyl beta-ketoester starting materials.

SUBMITTER: Marinescu SC

PROVIDER: S-EPMC2966305 | biostudies-literature | 2008 Mar

REPOSITORIES: biostudies-literature

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Homogeneous pd-catalyzed enantioselective decarboxylative protonation.

Marinescu Smaranda C SC Nishimata Toyoki T Mohr Justin T JT Stoltz Brian M BM

Organic letters 20080228 6

General homogeneous conditions for the palladium-catalyzed synthesis of carbonyl compounds with tertiary carbon stereocenters at the alpha-position are reported. The highly reactive catalyst tolerates a variety of substrate substitution and functionality, and generates enantioenriched cyclic ketones from racemic allyl beta-ketoester starting materials. ...[more]

PMID: 18303896

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