Ontology highlight
ABSTRACT:
SUBMITTER: Um K
PROVIDER: S-EPMC4111230 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Developmental cell 20140601 6
The small GTPase Rac1 orchestrates actin-dependent remodeling essential for numerous cellular processes including synapse development. While precise spatiotemporal regulation of Rac1 is necessary for its function, little is known about the mechanisms that enable Rac1 activators (GEFs) and inhibitors (GAPs) to act in concert to regulate Rac1 signaling. Here, we identify a regulatory complex composed of a Rac-GEF (Tiam1) and a Rac-GAP (Bcr) that cooperate to control excitatory synapse development. ...[more]