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1-Dichloro-acetyl-r-2,c-6-bis-(4-methoxy-phen-yl)-c-3,t-3-dimethyl-piperidin-4-one.

ABSTRACT: In the title compound, C(23)H(25)Cl(2)NO(4), the piperidine ring adopts a distorted boat conformation. Inversion-related mol-ecules are linked into centrosymmetric R(2) (2)(16) dimers by paired C-H⋯O hydrogen bonds, and the dimers are connected via C-H⋯O hydrogen bonds into a chain running along [101].

SUBMITTER: Thenmozhi M

PROVIDER: S-EPMC2967932 | biostudies-literature |

REPOSITORIES: biostudies-literature

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1-Chloro-acetyl-2,6-bis-(2-methoxy-phen-yl)-3,5-dimethyl-piperidin-4-one.

Project description:The piperidone ring in the title compound, C(23)H(26)ClNO(4), adopts a boat conformation with its two out-of-plane C atoms deviating by 0.597 (2) and 0.630 (2) Å from the least-squares plane of the rest of atoms in the ring. The two aromatic rings are roughly perpendicular to each other, making a dihedral angle of 75.1 (1)°, and a C-H⋯π intra-molecular inter-action is observed. The crystal packing is stabilized by a C-H⋯O inter-molecular inter-action, generating a chain with a C(9) motif along the a axis.

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1-Bromo-acetyl-2,6-bis-(4-methoxy-phen-yl)-3,5-dimethyl-piperidin-4-one.

Project description:In the title compound, C(23)H(26)BrNO(4), the piperidinone ring adopts a boat conformation. The dihedral angle between the two benzene rings is 70.9 (1)°. The two meth-oxy groups are close to coplanar with the attached benzene rings [C-C-O-C torsion angles of 6.3 (5) and 16.4 (4)°]. A weak C-H⋯Br intra-molecular inter-action is observed. In the crystal structure, mol-ecules are linked into a chain along [101] by inter-molecular C-H⋯O hydrogen bonds. A short inter-molecular Br⋯O contact [3.063 (2) Å] is observed.

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1-Dichloro-acetyl-r-2,c-6-bis-(4-methoxy-phen-yl)-t-3,t-5-dimethyl-piperidin-4-one.

Project description:In the title compound, C(23)H(25)Cl(2)NO(4), the piperidine ring adopts a distorted boat conformation. The dihedral angle between the benzene rings is 54.8 (1)°. In the crystal, the mol-ecules are linked into a two-dimensional network parallel to the ab plane by C-H⋯O hydrogen bonds.

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1-Dichloro-acetyl-r-2,c-6-bis-(4-methoxy-phen-yl)-t-3-methyl-piperidin-4-one.

Project description:In the title compound, C(22)H(23)Cl(2)NO(4), the piperidine ring adopts a distorted boat conformation. The meth-oxy groups lie in the plane of the benzene rings to which they are attached. The benzene rings are oriented at angles of 84.3 (1) and 76.8 (1)° with respect to the best plane through the piperidine ring. The crystal packing is stabilized by intermolecular C-H⋯O inter-actions.

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1-Chloro-acetyl-r-2,c-6-bis-(4-methoxy-phen-yl)-c-3,t-3-dimethyl-piperidin-4-one.

Project description:In the title compound, C(23)H(26)ClNO(4), the piperidine ring adopts a distorted boat conformation. The two methoxy-phenyl groups at the 2 and 6 positions of the piperidine ring are in axial and equatorial orientations. An intra-molecular C-H?Cl inter-action is observed. In the crystal, the mol-ecules are linked into zigzag chains along the b axis by C-H?? inter-molecular inter-actions.

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1-Chloro-acetyl-2,6-bis-(2-chloro-phen-yl)-3,5-dimethyl-piperidin-4-one.

Project description:In the title compound, C(21)H(20)Cl(3)NO(2), the piperidin-4-one ring adopts a boat conformation. The two 2-chloro-phenyl groups are approximately perpendicular to each other, making a dihedral angle of 74.07 (8)°.

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Project description:In the title compound, C(21)H(21)Cl(3)N(2)O(2), the piperidine ring adopts a distorted boat conformation. One of the chloro-phenyl rings is almost perpendicular to the best plane through piperidine ring, making a dihedral angle of 88.7?(1)°, whereas the other ring is twisted by 71.8?(1)°. The crystal packing is stabilized by inter-molecular C-H?O, C-H?Cl and O-H?O inter-actions.

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1-Acetyl-t-3-ethyl-r-2,c-6-bis-(4-methoxy-phen-yl)piperidin-4-one.

Project description:In the title compound, C(23)H(27)NO(4), the piperidine ring adopts a distorted boat conformation. The meth-oxy groups lie in the plane of benzene rings to which they are attached [maximum deviations of 0.014 (3) and 0.007 (3) Å]. The benzene rings are oriented at angles of 67.2 (1) and 87.0 (1)° with respect to the best plane through the four co-planar atoms of the piperidine ring.

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2,6-Bis(3-methoxy-phen-yl)-3-methyl-piperidin-4-one.

Project description:In the mol-ecule of the title compound, C(20)H(23)NO(3), the bulky methoxy-phenyl substituents at the equatorial 2,6-positions crowd the vicinity of the equatorial amino H atom and prevent it from forming inter-molecular hydrogen bonds. The piperidine ring adopts a distorted chair conformation.

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r-2,c-6-Bis(3-methoxy-phen-yl)-t-3,t-5-dimethyl-piperidin-4-one.

Project description:In the title compound, C(21)H(25)NO(3), the piperidinone ring adopts a chair conformation with an equatorial orientation of all substituents; the 3-methoxy-phenyl groups make a dihedral angle of 60.26 (15)°. The carbonyl group O atom is disordered over two positions in a 0.643 (3):0.357 (3) ratio. The crystal structure is stabilized by N-H⋯O and C-H⋯O hydrogen bonding.

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