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1-Dichloro-acetyl-r-2,c-6-bis-(4-methoxy-phen-yl)-t-3-methyl-piperidin-4-one.

ABSTRACT: In the title compound, C(22)H(23)Cl(2)NO(4), the piperidine ring adopts a distorted boat conformation. The meth-oxy groups lie in the plane of the benzene rings to which they are attached. The benzene rings are oriented at angles of 84.3 (1) and 76.8 (1)° with respect to the best plane through the piperidine ring. The crystal packing is stabilized by intermolecular C-H⋯O inter-actions.

SUBMITTER: Ravichandran K

PROVIDER: S-EPMC2979921 | biostudies-literature |

REPOSITORIES: biostudies-literature

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2,6-Bis(3-methoxy-phen-yl)-3-methyl-piperidin-4-one.

Project description:In the mol-ecule of the title compound, C(20)H(23)NO(3), the bulky methoxy-phenyl substituents at the equatorial 2,6-positions crowd the vicinity of the equatorial amino H atom and prevent it from forming inter-molecular hydrogen bonds. The piperidine ring adopts a distorted chair conformation.

| S-EPMC2972106 | biostudies-literature

1-Chloro-acetyl-r-2,c-6-bis-(4-methoxy-phen-yl)-t-3-methyl-piperidin-4-one.

Project description:There are two crystallographically independent mol-ecules in the asymmetric unit of the title compound, C(22)H(24)ClNO(4). The piperidine ring in both mol-ecules adopts a distorted boat conformation. The crystal packing is stabilized by C-H?O and C-H?Cl inter-actions.

| S-EPMC2971376 | biostudies-literature

1-Dichloro-acetyl-r-2,c-6-bis-(4-methoxy-phen-yl)-t-3,t-5-dimethyl-piperidin-4-one.

Project description:In the title compound, C(23)H(25)Cl(2)NO(4), the piperidine ring adopts a distorted boat conformation. The dihedral angle between the benzene rings is 54.8 (1)°. In the crystal, the mol-ecules are linked into a two-dimensional network parallel to the ab plane by C-H⋯O hydrogen bonds.

| S-EPMC2979939 | biostudies-literature

1-Dichloro-acetyl-r-2,c-6-bis-(4-methoxy-phen-yl)-c-3,t-3-dimethyl-piperidin-4-one.

Project description:In the title compound, C(23)H(25)Cl(2)NO(4), the piperidine ring adopts a distorted boat conformation. Inversion-related mol-ecules are linked into centrosymmetric R(2) (2)(16) dimers by paired C-H⋯O hydrogen bonds, and the dimers are connected via C-H⋯O hydrogen bonds into a chain running along [101].

| S-EPMC2967932 | biostudies-literature

1-Chloro-acetyl-2,6-bis-(2-methoxy-phen-yl)-3,5-dimethyl-piperidin-4-one.

Project description:The piperidone ring in the title compound, C(23)H(26)ClNO(4), adopts a boat conformation with its two out-of-plane C atoms deviating by 0.597?(2) and 0.630?(2)?Å from the least-squares plane of the rest of atoms in the ring. The two aromatic rings are roughly perpendicular to each other, making a dihedral angle of 75.1?(1)°, and a C-H?? intra-molecular inter-action is observed. The crystal packing is stabilized by a C-H?O inter-molecular inter-action, generating a chain with a C(9) motif along the a axis.

| S-EPMC2970045 | biostudies-literature

1-Bromo-acetyl-2,6-bis-(4-methoxy-phen-yl)-3,5-dimethyl-piperidin-4-one.

Project description:In the title compound, C(23)H(26)BrNO(4), the piperidinone ring adopts a boat conformation. The dihedral angle between the two benzene rings is 70.9?(1)°. The two meth-oxy groups are close to coplanar with the attached benzene rings [C-C-O-C torsion angles of 6.3?(5) and 16.4?(4)°]. A weak C-H?Br intra-molecular inter-action is observed. In the crystal structure, mol-ecules are linked into a chain along [101] by inter-molecular C-H?O hydrogen bonds. A short inter-molecular Br?O contact [3.063?(2)?Å] is observed.

| S-EPMC2959452 | biostudies-literature

1-Acetyl-t-3-ethyl-r-2,c-6-bis-(4-methoxy-phen-yl)piperidin-4-one.

Project description:In the title compound, C(23)H(27)NO(4), the piperidine ring adopts a distorted boat conformation. The meth-oxy groups lie in the plane of benzene rings to which they are attached [maximum deviations of 0.014?(3) and 0.007?(3)?Å]. The benzene rings are oriented at angles of 67.2?(1) and 87.0?(1)° with respect to the best plane through the four co-planar atoms of the piperidine ring.

| S-EPMC2979765 | biostudies-literature

1-Methyl-3,3-bis-[(4-methyl-phen-yl)sulfan-yl]piperidin-2-one.

Project description:The piperidone ring in the title compound, C(20)H(23)NOS(2), has a half-chair distorted to a twisted-boat conformation [Q(T) = 0.5200?(17)?Å]. One of the S-bound benzene rings is almost perpendicular to the least-squares plane through the piperidone ring, whereas the other is not [dihedral angles = 75.28?(5) and 46.41?(5)?Å, respectively]. In the crystal, the presence of C-H?O and C-H?? inter-actions leads to the formation of supra-molecular layers in the ab plane.

| S-EPMC3201309 | biostudies-literature

1-Formyl-r-2,c-6-bis-(4-methoxy-phen-yl)-t-3-methyl-piperidin-4-one.

Project description:The asymmetric unit of the title compound, C(21)H(23)NO(4), contains two crystallographically independent mol-ecules A and B. In both mol-ecules, the piperidine-4-one rings adopt a distorted twist-boat conformation. The formyl group at position 1, the methoxy-phenyl ring at position 2 and the methyl group at position 3 are attached equatorially. The meth-oxy phenyl ring at position 6 has an axial orientation. The dihedral angle between the two benzene rings is 55.27?(8)° in mol-ecule A, and 55.29?(8)° in mol-ecule B. In the crystal, the mol-ecules are linked by weak C-H?O inter-molecular hydrogen-bond inter-actions. In addition, weak C-H?? inter-molecular inter-actions involving the benzene rings at positions 6 and 2 of mol-ecule B are also found in the crystal structure.

| S-EPMC2971181 | biostudies-literature

1-Chloro-acetyl-2,6-bis-(3-fluoro-phen-yl)piperidin-4-one.

Project description:In the title compound C(19)H(16)ClF(2)NO(2), the piperidone ring adopts a twist-boat conformation with the two out-of-plane atoms deviating by 0.544?(1) and 0.511?(1)?Å from the plane through the remaining atoms in the ring. Sterically favoured non-H-atom C?O inter-molecular contacts are observed in the structure, within a 3.00?Å range. The crystal packing is stabilized by C-H?O and C-H?F hydrogen bonds and an inter-molecular ?-? inter-action [centroid-centroid separation of 3.783?(1)?Å]. Alternating C-H?O and C-H?F inter-molecular inter-actions generate chains running along the a axis, while a centrosymmetric R(2) (2)(16) ring involving C-H?O inter-actions is formed centred at (1/2, 1/2, 0).

| S-EPMC2977122 | biostudies-literature

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