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Cis-Diammine(glycolato-?O,O)platinum(II).

ABSTRACT: The reaction of cis-[Pt(NO(3))(2)(NH(3))(2)] and sodium glycolate yielded the title compound, [Pt(C(2)H(2)O(3))(NH(3))(2)]. The Pt(II) atom, coordinated by two N atoms of ammine and two O atoms of the carboxyl-ate and oxido groups of the glycolate ligand, is in a square-planar environment. In the crystal structure, mol-ecules are connected by inter-molecular N-H?O hydrogen bonds, forming a three-dimensional network.

SUBMITTER: Wang QK

PROVIDER: S-EPMC2972061 | biostudies-literature | 2009 Nov

REPOSITORIES: biostudies-literature

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cis-Diammine(glycolato-κO,O)platinum(II).

Wang Qing-Kun QK Pu Shao-Ping SP Cong Yan-Wei YW Li Yong-Nian YN Luan Chun-Fang CF

Acta crystallographica. Section E, Structure reports online 20091128 Pt 12

The reaction of cis-[Pt(NO(3))(2)(NH(3))(2)] and sodium glycolate yielded the title compound, [Pt(C(2)H(2)O(3))(NH(3))(2)]. The Pt(II) atom, coordinated by two N atoms of ammine and two O atoms of the carboxyl-ate and oxido groups of the glycolate ligand, is in a square-planar environment. In the crystal structure, mol-ecules are connected by inter-molecular N-H⋯O hydrogen bonds, forming a three-dimensional network. ...[more]

PMID: 21578692

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cis-Diammine(pyridine)chloroplatinum(II), a monofunctional platinum(II) antitumor agent: Uptake, structure, function, and prospects.

Project description:We have identified unique chemical and biological properties of a cationic monofunctional platinum(II) complex, cis-diammine(pyridine)chloroplatinum(II), cis-[Pt(NH(3))(2)(py)Cl](+) or cDPCP, a coordination compound previously identified to have significant anticancer activity in a mouse tumor model. This compound is an excellent substrate for organic cation transporters 1 and 2, also designated SLC22A1 and SLC22A2, respectively. These transporters are abundantly expressed in human colorectal cancers, where they mediate uptake of oxaliplatin, cis-[Pt(DACH)(oxalate)] (DACH = trans-R,R-1,2-diaminocyclohexane), an FDA-approved first-line therapy for colorectal cancer. Unlike oxaliplatin, however, cDPCP binds DNA monofunctionally, as revealed by an x-ray crystal structure of cis-{Pt(NH(3))(2)(py)}(2+) bound to the N7 atom of a single guanosine residue in a DNA dodecamer duplex. Although the quaternary structure resembles that of B-form DNA, there is a base-pair step to the 5' side of the Pt adduct with abnormally large shift and slide values, features characteristic of cisplatin intrastrand cross-links. cDPCP effectively blocks transcription from DNA templates carrying adducts of the complex, unlike DNA lesions of other monofunctional platinum(II) compounds like {Pt(dien)}(2+). cDPCP-DNA adducts are removed by the nucleotide excision repair apparatus, albeit much less efficiently than bifunctional platinum-DNA intrastrand cross-links. These exceptional characteristics indicate that cDPCP and related complexes merit consideration as therapeutic options for treating colorectal and other cancers bearing appropriate cation transporters.

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cis-Dichloridobis(triisopropoxy-phosphine)-platinum(II).

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cis-Dibromidobis(2-phenyl-pyridine-?N)platinum(II).

Project description:In the title complex, [PtBr(2)(C(11)H(9)N)(2)], the Pt(II) ion has a distorted cis-Br(2)N(2) square-planar coordination geometry defined by two N atoms from two 2-phenyl-pyridine (ppy) ligands and two Br(-) anions. The ppy ligands are not planar, the dihedral angles between the pyridine and benzene rings being 49.0?(3) and 47.3?(3)°. In the crystal, the complex mol-ecules are stacked in columns along the a axis. In the columns, there are numerous intra- and inter-molecular ?-? inter-actions between the six-membered rings, the shortest ring centroid-centroid distance being 3.774?(6)?Å.

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cis-Dimethyl-bis(triphenyl-arsine)platinum(II).

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cis-Dichloridobis(quinoline-?N)-platinum(II) nitro-methane monosolvate.

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Crystal structure of cis-diamminebis(nitrito-?N)platinum(II).

Project description:Single crystals of cis-[Pt(NO2)2(NH3)2], were obtained by means of hyper-saturation directly out of a plating electrolyte. The square-planar coordination environment of the divalent Pt(II) atom is formed by four N atoms belonging to two ammine and two monodentate nitrite ligands. The ligands adopt a cis configuration. The crystal structure contains stacks of close-packed mol-ecules which run parallel to [001]. There are nine crystallographically independent inter-molecular N-H?O hydrogen bonds, resulting in a hydrogen-bonded hxl-type framework in which each mol-ecule serves as an eight-connected node. Four of the nine distinct hydrogen bonds connect complexes which belong to the same close-packed column parallel to [001]. In contrast to the previously reported crystal structure of the trans isomer, the title structure does not display intra-molecular hydrogen bonding.

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Project description:The title compound, [PtCl(2)(C(20)H(17)P)(2)], forms a monomeric cis-square-planar geometry. The Pt-P bond lengths are 2.2489?(9) and 2.2627?(9)?Å, whereas the Pt-Cl bond lengths are 2.3566?(9) and 2.3336?(9)?Å.

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