Ontology highlight
ABSTRACT:
SUBMITTER: Kanai M
PROVIDER: S-EPMC2978787 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Kanai M M Crowe M S MS Zheng Y Y Vande Woude G F GF Fukasawa K K
Oncogene 20100809 45
CDK2-cyclin E triggers centrosome duplication, and nucleophosmin (NPM/B23) is found to be one of its targets. NPM/B23 phosphorylated by CDK2-cyclin E acquires a high binding affinity to Rho-associated kinase (ROCK II), and physically associates with ROCK II. The NPM/B23-binding results in superactivation of ROCK II, which is a critical event for initiation of centrosome duplication. The activation of ROCK II also requires the binding of Rho small GTPase to the auto-inhibitory region; hence the a ...[more]