Ontology highlight
ABSTRACT:
SUBMITTER: Zender L
PROVIDER: S-EPMC2990916 | biostudies-literature | 2008 Nov
REPOSITORIES: biostudies-literature
Cell 20081113 5
Cancers are highly heterogeneous and contain many passenger and driver mutations. To functionally identify tumor suppressor genes relevant to human cancer, we compiled pools of short hairpin RNAs (shRNAs) targeting the mouse orthologs of genes recurrently deleted in a series of human hepatocellular carcinomas and tested their ability to promote tumorigenesis in a mosaic mouse model. In contrast to randomly selected shRNA pools, many deletion-specific pools accelerated hepatocarcinogenesis in mic ...[more]