Ontology highlight
ABSTRACT:
SUBMITTER: Li X
PROVIDER: S-EPMC3005334 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Cell 20101028 4
Natural small compounds comprise most cellular molecules and bind proteins as substrates, products, cofactors, and ligands. However, a large-scale investigation of in vivo protein-small metabolite interactions has not been performed. We developed a mass spectrometry assay for the large-scale identification of in vivo protein-hydrophobic small metabolite interactions in yeast and analyzed compounds that bind ergosterol biosynthetic proteins and protein kinases. Many of these proteins bind small m ...[more]