Ontology highlight
ABSTRACT:
SUBMITTER: Yang Y
PROVIDER: S-EPMC3009788 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Yang Yoosoo Y Shin Jae Yoon JY Oh Jung-Mi JM Jung Chang Hwa CH Hwang Yunha Y Kim Sehyun S Kim Jun-Seob JS Yoon Kee-Jung KJ Ryu Ji-Young JY Shin Jaeil J Hwang Jae Sung JS Yoon Tae-Young TY Shin Yeon-Kyun YK Kweon Dae-Hyuk DH
Proceedings of the National Academy of Sciences of the United States of America 20101206 51
Neuronal SNARE proteins mediate neurotransmitter release at the synapse by facilitating the fusion of vesicles to the presynaptic plasma membrane. Cognate v-SNAREs and t-SNAREs from the vesicle and the plasma membrane, respectively, zip up and bring about the apposition of two membranes attached at the C-terminal ends. Here, we demonstrate that SNARE zippering can be modulated in the midways by wedging with small hydrophobic molecules. Myricetin, which intercalated into the hydrophobic inner cor ...[more]