Ontology highlight
ABSTRACT:
SUBMITTER: McDargh ZA
PROVIDER: S-EPMC6298751 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
McDargh Zachary A ZA Polley Anirban A O'Shaughnessy Ben B
FEBS letters 20181102 21
SNARE proteins constitute the core of the exocytotic membrane fusion machinery. Fusion occurs when vesicle-associated and target membrane-associated SNAREs zipper into trans-SNARE complexes ('SNAREpins'), but the number required is controversial and the mechanism of cooperative fusion is poorly understood. We developed a highly coarse-grained molecular dynamics simulation to access the long fusion timescales, which revealed a two-stage process. First, zippering energy was dissipated and cooperat ...[more]