Ontology highlight
ABSTRACT:
SUBMITTER: Liang Q
PROVIDER: S-EPMC3036903 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
Liang Qiaoyi Q Ding Jiayi J Zheng Shu S
Genetics and molecular biology 20091001 4
Up-regulation of human endogenous retroviruses (HERVs) is associated with many diseases, including cancer. In this study, an H family HERV (HERV-H)-related gene was identified and characterized. Its spliced transcript lacks protein-coding capacity and may belong to the emerging class of noncoding RNAs (ncRNAs). The 1.3-kb RNA consisting of four exons is transcribed from an Alu element upstream of a 5.0-kb structurally incomplete HERV-H element. RT-PCR and quantitative RT-PCR results indicated th ...[more]