Ontology highlight
ABSTRACT:
SUBMITTER: Yamamizu K
PROVIDER: S-EPMC5355679 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Yamamizu Kohei K Iwasaki Mio M Takakubo Hitomi H Sakamoto Takumi T Ikuno Takeshi T Miyoshi Mami M Kondo Takayuki T Nakao Yoichi Y Nakagawa Masato M Inoue Haruhisa H Yamashita Jun K JK
Stem cell reports 20170223 3
The blood-brain barrier (BBB) is composed of four cell populations, brain endothelial cells (BECs), pericytes, neurons, and astrocytes. Its role is to precisely regulate the microenvironment of the brain through selective substance crossing. Here we generated an in vitro model of the BBB by differentiating human induced pluripotent stem cells (hiPSCs) into all four populations. When the four hiPSC-derived populations were co-cultured, endothelial cells (ECs) were endowed with features consistent ...[more]