Ontology highlight
ABSTRACT:
SUBMITTER: Fresta CG
PROVIDER: S-EPMC7084779 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
International journal of molecular sciences 20200227 5
Blood-retinal barrier (BRB) dysfunction represents one of the most significant changes occurring during diabetic retinopathy. We set up a high-reproducible human-based in vitro BRB model using retinal pericytes, retinal astrocytes, and retinal endothelial cells in order to replicate the human in vivo environment with the same numerical ratio and layer order. Our findings showed that high glucose exposure elicited BRB breakdown, enhanced permeability, and reduced the levels of junction proteins s ...[more]