Ontology highlight
ABSTRACT:
SUBMITTER: Watanabe D
PROVIDER: S-EPMC8470770 | biostudies-literature | 2021 Sep
REPOSITORIES: biostudies-literature
Watanabe Daisuke D Nakagawa Shinsuke S Morofuji Yoichi Y Tóth Andrea E AE Vastag Monika M Aruga Jun J Niwa Masami M Deli Mária A MA
Pharmaceutics 20210916 9
Culture models of the blood-brain barrier (BBB) are important research tools. Their role in the preclinical phase of drug development to estimate the permeability for potential neuropharmaceuticals is especially relevant. Since species differences in BBB transport systems exist, primate models are considered as predictive for drug transport to brain in humans. Based on our previous expertise we have developed and characterized a non-human primate co-culture BBB model using primary cultures of mo ...[more]