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2-[4-(2-Meth-oxy-phen-yl)piperazin-1-yl]-N-(pyridin-2-yl)acetamide.

ABSTRACT: In the title compound, C(18)H(22)N(4)O(2), the piperizine ring adopts a chair conformation and the dihedral angle between the pyridine and benzene rings is 67.6?(9)°. The conformations of the attachment of the anisole and N-ethyl-pyridin-2-amine groups to the piperazine ring are (+)anti-periplanar. Intra-molecular C-H?O and N-H?N inter-actions occur. In the crystal, inter-molecular C-H?N hydrogen bonds are present. There are two crystallographically independent but identical mol-ecules per asymmetric unit.

SUBMITTER: Lu C

PROVIDER: S-EPMC3050313 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature

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2-[4-(2-Meth-oxy-phen-yl)piperazin-1-yl]-N-(pyridin-2-yl)acetamide.

Lu Chunxiong C Jiang Quanfu Q

Acta crystallographica. Section E, Structure reports online 20101224 Pt 1

In the title compound, C(18)H(22)N(4)O(2), the piperizine ring adopts a chair conformation and the dihedral angle between the pyridine and benzene rings is 67.6 (9)°. The conformations of the attachment of the anisole and N-ethyl-pyridin-2-amine groups to the piperazine ring are (+)anti-periplanar. Intra-molecular C-H⋯O and N-H⋯N inter-actions occur. In the crystal, inter-molecular C-H⋯N hydrogen bonds are present. There are two crystallographically independent but identical mol-ecules per asymm ...[more]

PMID: 21522722

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N-[(R)-(6-Bromo-2-meth-oxy-quinolin-3-yl)(phen-yl)meth-yl]-N-[(S)-1-(4-meth-oxy-phen-yl)eth-yl]-2-(piperazin-1-yl)acetamide.

Project description:In the title compound, C(32)H(35)BrN(4)O(3), the piperazine ring exists in a chair conformation. The quinoline ring system is oriented at dihedral angles of 82.70?(17) and 19.54?(17)° to the phenyl and meth-oxy-phenyl rings, respectively. Weak inter-molecular C-H?? inter-actions are present in the crystal structure.

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N-{2-[4-(2-Meth-oxy-phen-yl)piperazin-1-yl]eth-yl}pyridin-2-amine monohydrate.

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N-{4-[(2-Meth-oxy-phen-yl)sulfamo-yl]phen-yl}acetamide.

Project description:In the title compound, C(15)H(16)N(2)O(4)S, the S atom has a distorted tetra-hedral geometry [maximum deviation: O-S-O = 118.25 (7)°]. The two aromatic rings make a dihedral angle of 62.67 (10)° with each other. An intra-molecular N-H⋯O hydrogen bond forms an S(6) ring motif. In the crystal, mol-ecules form centrosymmetric dimers via pairwise N-H⋯O inter-actions, forming an R(2) (2)(8) ring motif, and these dimers are connected by N-H⋯O hydrogen bonds, generating a three-dimensional network. Furthermore, a weak C-H⋯π inter-action helps to reinforce the crystal structure. The O atom in the acetamide group is disordered over two positions with major and minor occupancies of 0.52 (5) and 0.48 (5), respectively.

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Project description:In the title compound, C(16)H(16)N(2)O(5), the meth-oxy group is disordered with site occupancies of 0.20 (3) and 0.80 (3). The dihedral angle between the two aromatic rings is 73.7 (2)°. The crystal structure is characterized by intermolecular N-H⋯O, O-H⋯O, C-H⋯O and C-H⋯π hydrogen bonds.

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Project description:The title mol-ecule, C(17)H(14)F(3)NO(4), consists of two nearly planar fragments, viz. the 2-benzyl-oxypyridine (r.m.s. deviation 0.016?Å) and (E)-3-meth-oxy-prop2-enoic (r.m.s. deviation 0.004?Å) units, which form a dihedral angle of 84.19?(7)°. In the crystal, pairs of O-H?O hydrogen bonds link mol-ecules into dimers that are further connected by C-H?O and C-H?F inter-actions into (001) layers. In addition, ?-? stacking inter-actions are observed within a layer between the pyridine and benzene rings [centroid-centroid distance = 3.768?(2)?Å]. The F atoms of the trifluoro-methyl group are disordered over two sets of sites in a 0.53?(4):0.47?(4) ratio.

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<i>N</i>-(4-Meth-oxy-2-nitro-phen-yl)acetamide.

Project description:In the title compound, C9H10N2O4, the three substituents vary in the degree of lack of planarity with the central phenyl ring. The meth-oxy group is nearest to being coplanar, with a C-C-O-C torsion angle of 6.1 (5)°. The nitro group is less coplanar, with a 12.8 (5)° twist about the C-N bond and the acetamido group is considerably less coplanar with the central ring, having a 25.4 (5)° twist about the C-N bond to the ring. The NH group forms an intra-molecular N-H⋯O hydrogen bond to a nitro-group O atom.

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<i>N</i>-(4-Meth-oxy-3-nitro-phen-yl)acetamide.

Project description:The title compound, C9H10N2O4, crystallizes with a disordered nitro group in twinned crystals. Both the meth-oxy group and the acetamide groups are nearly coplanar with the phenyl ring, and the C-N-C-O torsion angle [0.2 (4)°] is also insignificantly different from zero. Overall, the 12-atom meth-oxy-phenyl-acetamide group is nearly planar, with an r.m.s. deviation of 0.042 Å. The nitro group is twisted out of this plane by about 30°, disordered into two orientations with opposite senses of twist. In the crystal, the N-H group donates a hydrogen bond to a nitro oxygen atom, generating chains propagating in the [101] direction. The amide carbonyl oxygen atom is not involved in the hydrogen bonding.

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N-[(2-Hydr-oxy-1-naphth-yl)(2-hydroxy-phen-yl)meth-yl]acetamide.

Project description:In the asymmetric unit of the title compound, C(19)H(17)NO(3), there are two crystallographically independent mol-ecules, which are connected to each other by O-H?O hydrogen bonds, forming mol-ecular chains as well as cyclic centrosymmetric R(2) (2)(16) dimers.

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