Ontology highlight
ABSTRACT:
SUBMITTER: Margolis DJ
PROVIDER: S-EPMC3050548 | biostudies-literature | 2008 Jun
REPOSITORIES: biostudies-literature
Margolis David J DJ Newkirk Gregory G Euler Thomas T Detwiler Peter B PB
The Journal of neuroscience : the official journal of the Society for Neuroscience 20080601 25
Glutamate released from photoreceptors controls the activity and output of parallel pathways in the retina. When photoreceptors die because of degenerative diseases, surviving retinal networks are left without their major source of input, but little is known about how photoreceptor loss affects ongoing synaptic activity and retinal output. Here, we use patch-clamp recording and two-photon microscopy to investigate morphological and physiological properties of identified types of ON and OFF retin ...[more]