Ontology highlight
ABSTRACT:
SUBMITTER: Popkin DL
PROVIDER: S-EPMC3058147 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Popkin Daniel L DL Teijaro John R JR Sullivan Brian M BM Urata Shuzo S Rutschmann Sophie S de la Torre Juan Carlos JC Kunz Stefan S Beutler Bruce B Oldstone Michael M
Cell host & microbe 20110301 3
The prototypic arenavirus lymphocytic choriomeningitis virus (LCMV), which naturally persists in rodents, represents a model for HIV, HBV, and HCV. Cleavage of the viral glycoprotein precursor by membrane-bound transcription factor peptidase, site 1 (Mbtps1 or site-1 protease), is crucial for the life cycle of arenaviruses and therefore represents a potential target for therapy. Recently, we reported a viable hypomorphic allele of Mbtps1 (woodrat) encoding a protease with diminished enzymatic ac ...[more]