Ontology highlight
ABSTRACT:
SUBMITTER: Graziano BR
PROVIDER: S-EPMC3653363 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
The Journal of cell biology 20130501 4
Formins associate with other nucleators and nucleation-promoting factors (NPFs) to stimulate collaborative actin assembly, but the mechanisms regulating these interactions have been unclear. Yeast Bud6 has an established role as an NPF for the formin Bni1, but whether it also directly regulates the formin Bnr1 has remained enigmatic. In this paper, we analyzed NPF-impaired alleles of bud6 in a bni1Δ background and found that Bud6 stimulated Bnr1 activity in vivo. Furthermore, Bud6 bound directly ...[more]