Ontology highlight
ABSTRACT:
SUBMITTER: Chalifoux JR
PROVIDER: S-EPMC3061967 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Chalifoux Jason R JR Carter Adam G AG
The Journal of neuroscience : the official journal of the Society for Neuroscience 20110301 11
Although primarily studied at the cell body, GABA(B) receptors (GABA(B)Rs) are abundant at spines and dendrites of cortical pyramidal neurons, where they are positioned to influence both synaptic and dendritic function. Here, we examine how GABA(B)Rs modulate calcium (Ca) signals evoked by action potentials (APs) in spines and dendrites of layer 2/3 pyramidal neurons in mouse prefrontal cortex. We first use two-photon microscopy to show that GABA(B)Rs inhibit AP Ca signals throughout the entire ...[more]