Ontology highlight
ABSTRACT:
SUBMITTER: Wun KS
PROVIDER: S-EPMC3064745 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Immunity 20110303 3
Natural killer T (NKT) cells respond to a variety of CD1d-restricted antigens (Ags), although the basis for Ag discrimination by the NKT cell receptor (TCR) is unclear. Here we have described NKT TCR fine specificity against several closely related Ags, termed altered glycolipid ligands (AGLs), which differentially stimulate NKT cells. The structures of five ternary complexes all revealed similar docking. Acyl chain modifications did not affect the interaction, but reduced NKT cell proliferation ...[more]