Ontology highlight
ABSTRACT:
SUBMITTER: Jiang N
PROVIDER: S-EPMC3069157 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Jiang Ning N Weinstein Joshua A JA Penland Lolita L White Richard A RA Fisher Daniel S DS Quake Stephen R SR
Proceedings of the National Academy of Sciences of the United States of America 20110310 13
It is thought that the adaptive immune system of immature organisms follows a more deterministic program of antibody creation than is found in adults. We used high-throughput sequencing to characterize the diversifying antibody repertoire in zebrafish over five developmental time points. We found that the immune system begins in a highly stereotyped state with preferential use of a small number of V (variable) D (diverse) J (joining) gene segment combinations, but that this stereotypy decreases ...[more]