Ontology highlight
ABSTRACT:
SUBMITTER: Castoldi M
PROVIDER: S-EPMC3069782 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Castoldi Mirco M Vujic Spasic Maja M Altamura Sandro S Elmén Joacim J Lindow Morten M Kiss Judit J Stolte Jens J Sparla Richard R D'Alessandro Lorenza A LA Klingmüller Ursula U Fleming Robert E RE Longerich Thomas T Gröne Hermann J HJ Benes Vladimir V Kauppinen Sakari S Hentze Matthias W MW Muckenthaler Martina U MU
The Journal of clinical investigation 20110401 4
Systemic iron homeostasis is mainly controlled by the liver through synthesis of the peptide hormone hepcidin (encoded by Hamp), the key regulator of duodenal iron absorption and macrophage iron release. Here we show that the liver-specific microRNA miR-122 is important for regulating Hamp mRNA expression and tissue iron levels. Efficient and specific depletion of miR-122 by injection of a locked-nucleic-acid-modified (LNA-modified) anti-miR into WT mice caused systemic iron deficiency, characte ...[more]