Ontology highlight
ABSTRACT:
SUBMITTER: Pol A
PROVIDER: S-EPMC307531 | biostudies-literature | 2004 Jan
REPOSITORIES: biostudies-literature
Pol Albert A Martin Sally S Fernandez Manuel A MA Ferguson Charles C Carozzi Amanda A Luetterforst Robert R Enrich Carlos C Parton Robert G RG
Molecular biology of the cell 20031003 1
Caveolins are a crucial component of caveolae but have also been localized to the Golgi complex, and, under some experimental conditions, to lipid bodies (LBs). The physiological relevance and dynamics of LB association remain unclear. We now show that endogenous caveolin-1 and caveolin-2 redistribute to LBs in lipid loaded A431 and FRT cells. Association with LBs is regulated and reversible; removal of fatty acids causes caveolin to rapidly leave the lipid body. We also show by subcellular frac ...[more]