Ontology highlight
ABSTRACT:
SUBMITTER: Pol A
PROVIDER: S-EPMC2198820 | biostudies-other | 2001 Mar
REPOSITORIES: biostudies-other
Pol A A Luetterforst R R Lindsay M M Heino S S Ikonen E E Parton R G RG
The Journal of cell biology 20010301 5
Recent studies have indicated a role for caveolin in regulating cholesterol-dependent signaling events. In the present study we have analyzed the role of caveolins in intracellular cholesterol cycling using a dominant negative caveolin mutant. The mutant caveolin protein, cav-3(DGV), specifically associates with the membrane surrounding large lipid droplets. These structures contain neutral lipids, and are accessed by caveolin 1-3 upon overexpression. Fluorescence, electron, and video microscopy ...[more]