Ontology highlight
ABSTRACT:
SUBMITTER: Karalay O
PROVIDER: S-EPMC3078392 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Karalay Ozlem O Doberauer Kathrin K Vadodaria Krishna C KC Knobloch Marlen M Berti Lucia L Miquelajauregui Amaya A Schwark Manuela M Jagasia Ravi R Taketo Makoto M MM Tarabykin Victor V Lie D Chichung DC Jessberger Sebastian S
Proceedings of the National Academy of Sciences of the United States of America 20110321 14
Neural stem cells (NSCs) generate new granule cells throughout life in the mammalian hippocampus. Canonical Wnt signaling regulates the differentiation of NSCs towards the neuronal lineage. Here we identified the prospero-related homeodomain transcription factor Prox1 as a target of β-catenin-TCF/LEF signaling in vitro and in vivo. Prox1 overexpression enhanced neuronal differentiation whereas shRNA-mediated knockdown of Prox1 impaired the generation of neurons in vitro and within the hippocampa ...[more]