Crystallization and preliminary crystallographic characterization of three peptidic inhibitors in complex with ?-thrombin.

ABSTRACT: The serine protease thrombin plays a major role in thrombosis and haemostasis. This has driven interest in thrombin inhibitors as potential antithrombotic drugs. Here, the crystallization and preliminary crystallographic analysis of human ?-thrombin in complex with three noncovalent peptide inhibitors of the general sequence D-Phe-Pro-D-Arg-P1'-CONH2 are reported. The crystals belonged to the orthorhombic space group P2(1)2(1)2(1) and diffracted to beyond 1.3?Å resolution.

SUBMITTER: Carvalho Figueiredo A 

PROVIDER: S-EPMC3079972 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature