Unknown

Dataset Information

0

Large-scale asymmetric synthesis of the bioprotective agent JP4-039 and analogs.


ABSTRACT: JP4-039 is a novel nitroxide conjugate capable of crossing lipid bilayer membranes and scavenging reactive oxygen species (ROS). An efficient and scalable one-pot hydrozirconation-transmetalation-imine addition methodology has been developed for its asymmetric preparation. Furthermore, this versatile methodology allows for the synthesis of cyclopropyl and fluorinated analogs of the parent lead structure.

SUBMITTER: Frantz MC 

PROVIDER: S-EPMC3089766 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature

altmetric image

Publications

Large-scale asymmetric synthesis of the bioprotective agent JP4-039 and analogs.

Frantz Marie-Céline MC   Pierce Joshua G JG   Pierce Joan M JM   Kangying Li L   Qingwei Wan W   Johnson Matthew M   Wipf Peter P  

Organic letters 20110331 9


JP4-039 is a novel nitroxide conjugate capable of crossing lipid bilayer membranes and scavenging reactive oxygen species (ROS). An efficient and scalable one-pot hydrozirconation-transmetalation-imine addition methodology has been developed for its asymmetric preparation. Furthermore, this versatile methodology allows for the synthesis of cyclopropyl and fluorinated analogs of the parent lead structure. ...[more]

Similar Datasets

| S-EPMC3729477 | biostudies-literature
| S-EPMC5767136 | biostudies-literature
| S-EPMC6554705 | biostudies-literature
| S-EPMC4773657 | biostudies-literature
| S-EPMC6199586 | biostudies-literature
| S-EPMC4709638 | biostudies-literature
| S-EPMC5794877 | biostudies-other
| S-EPMC6155351 | biostudies-literature
| S-EPMC6477534 | biostudies-literature
| S-EPMC5973476 | biostudies-literature