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Synthesis of analogs of the radiation mitigator JP4-039 and visualization of BODIPY derivatives in mitochondria.


ABSTRACT: JP4-039 is a lead structure in a series of nitroxide conjugates that are capable of accumulating in mitochondria and scavenging reactive oxygen species (ROS). To explore structure-activity relationships (SAR), new analogs with variable nitroxide moieties were prepared. Furthermore, fluorophore-tagged analogs were synthesized and provided the opportunity for visualization in mitochondria. All analogs were tested for radioprotective and radiomitigative effects in 32Dcl3 cells.

SUBMITTER: Frantz MC 

PROVIDER: S-EPMC3729477 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature

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Synthesis of analogs of the radiation mitigator JP4-039 and visualization of BODIPY derivatives in mitochondria.

Frantz Marie-Céline MC   Skoda Erin M EM   Sacher Joshua R JR   Epperly Michael W MW   Goff Julie P JP   Greenberger Joel S JS   Wipf Peter P  

Organic & biomolecular chemistry 20130701 25


JP4-039 is a lead structure in a series of nitroxide conjugates that are capable of accumulating in mitochondria and scavenging reactive oxygen species (ROS). To explore structure-activity relationships (SAR), new analogs with variable nitroxide moieties were prepared. Furthermore, fluorophore-tagged analogs were synthesized and provided the opportunity for visualization in mitochondria. All analogs were tested for radioprotective and radiomitigative effects in 32Dcl3 cells. ...[more]

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