Ontology highlight
ABSTRACT:
SUBMITTER: Frantz MC
PROVIDER: S-EPMC3729477 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Frantz Marie-Céline MC Skoda Erin M EM Sacher Joshua R JR Epperly Michael W MW Goff Julie P JP Greenberger Joel S JS Wipf Peter P
Organic & biomolecular chemistry 20130701 25
JP4-039 is a lead structure in a series of nitroxide conjugates that are capable of accumulating in mitochondria and scavenging reactive oxygen species (ROS). To explore structure-activity relationships (SAR), new analogs with variable nitroxide moieties were prepared. Furthermore, fluorophore-tagged analogs were synthesized and provided the opportunity for visualization in mitochondria. All analogs were tested for radioprotective and radiomitigative effects in 32Dcl3 cells. ...[more]