Ontology highlight
ABSTRACT:
SUBMITTER: Epperly MW
PROVIDER: S-EPMC6199586 | biostudies-literature | 2018 Sep-Oct
REPOSITORIES: biostudies-literature
Epperly Michael W MW Wipf Peter P Fisher Renee R Franicola Darcy D Beumer Jan J Li Song S Brand Rhonda M RM Falo Louis D LD Erdos Geza G Greenberger Joel S JS
In vivo (Athens, Greece) 20180901 5
<h4>Background/aim</h4>The mitochondrial targeted GS-nitroxide, JP4-039, is an effective total body irradiation (TBI) mitigator when delivered intravenously (IV) up to 72 h after exposure. Effective systemic and localized administration to oral cavity/oropharynx and esophagus has been demonstrated. The objective of the study was to establish alternatives to IV administration suitable for JP4-039 delivery to mass casualties.<h4>Materials and methods</h4>JP4-039 was administered to C57BL/6 mice by ...[more]