Ontology highlight
ABSTRACT:
SUBMITTER: Christner S
PROVIDER: S-EPMC5767136 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Christner Susan S Guo Jianxia J Parise Robert A RA Ringeval Melanie M Hoye Adam T AT Wipf Peter P Epperly Michael W MW Greenberger Joel S JS Beumer Jan H JH Eiseman Julie L JL
Journal of pharmaceutical and biomedical analysis 20171212
JP4-039 radio-protects prior to, and radio-mitigates after ionizing radiation by neutralizing reactive oxygen species. We developed and validated an LC-MS/MS assay for the quantitation of JP4-039 in murine plasma. Methanol protein precipitation of 50μL plasma was followed by isocratic reverse phase chromatography for a 6min run time, and electrospray positive mode ionization mass spectrometric detection. The plasma assay was linear from 1 to 1000ng/mL with appropriate accuracy (97.1-107.6%) and ...[more]