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Trifluoromethylation of Heterocycles in Water at Room Temperature.

ABSTRACT: Using a reaction medium containing nanoparticles consisting of commercially available TPGS-750-M in water, a combination of Langlois' reagent and t-BuOOH can be used to effect trifluoromethylation of several heterocyclic arrays, including heteroaromatics. These reactions take place at ambient temperatures, and the aqueous medium can be recycled.

SUBMITTER: Fennewald JC 

PROVIDER: S-EPMC4019426 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature

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Trifluoromethylation of Heterocycles in Water at Room Temperature.

Fennewald James C JC   Lipshutz Bruce H BH  

Green chemistry : an international journal and green chemistry resource : GC 20140301 3

Using a reaction medium containing nanoparticles consisting of commercially available TPGS-750-M in water, a combination of Langlois' reagent and <i>t</i>-BuOOH can be used to effect trifluoromethylation of several heterocyclic arrays, including heteroaromatics. These reactions take place at ambient temperatures, and the aqueous medium can be recycled. ...[more]

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