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New Chromones from a Marine-Derived Fungus, Arthrinium sp., and Their Biological Activity.

ABSTRACT: Five new chromone derivatives, arthones A?E (1?5), together with eight known biogenetically related cometabolites (6?13), were isolated from a deep-sea-derived fungus Arthrinium sp. UJNMF0008. Their structures were assigned by detailed analyses of spectroscopic data, while the absolute configurations of 1 and 5 were established by electronic circular dichroism (ECD) calculations and that of 2 was determined by modified Mosher ester method. Compounds 3 and 8 exhibited potent antioxidant property with DPPH and ABTS radical scavenging activities, with IC50 values ranging from 16.9 to 18.7 ?M. Meanwhile, no compounds indicated obvious bioactivity in our antimicrobial and anti-inflammatory assays at 50.0 ?M.

SUBMITTER: Bao J

PROVIDER: S-EPMC6222336 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature

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New Chromones from a Marine-Derived Fungus, Arthrinium sp., and Their Biological Activity.

Bao Jie J He Fei F Yu Jin-Hai JH Zhai Huijuan H Cheng Zhi-Qiang ZQ Jiang Cheng-Shi CS Zhang Yuying Y Zhang Yun Y Zhang Xiaoyong X Chen Guangying G Zhang Hua H

Molecules (Basel, Switzerland) 20180809 8

Five new chromone derivatives, arthones A⁻E (1⁻5), together with eight known biogenetically related cometabolites (6⁻13), were isolated from a deep-sea-derived fungus Arthrinium sp. UJNMF0008. Their structures were assigned by detailed analyses of spectroscopic data, while the absolute configurations of 1 and 5 were established by electronic circular dichroism (ECD) calculations and that of 2 was determined by modified Mosher ester method. ...[more]

PMID: 30096887

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