Ontology highlight
ABSTRACT:
SUBMITTER: Yan D
PROVIDER: S-EPMC31133 | biostudies-literature | 2001 Mar
REPOSITORIES: biostudies-literature
Yan D D Wallingford J B JB Sun T Q TQ Nelson A M AM Sakanaka C C Reinhard C C Harland R M RM Fantl W J WJ Williams L T LT
Proceedings of the National Academy of Sciences of the United States of America 20010301 7
Genetic studies have identified Drosophila Naked Cuticle (Nkd) as an antagonist of the canonical Wnt/beta-catenin signaling pathway, but its mechanism of action remains obscure [Zeng, W., Wharton, K. A., Jr., Mack, J. A., Wang, K., Gadbaw, M., et al. (2000) Nature (London) 403, 789--795]. Here we have cloned a cDNA encoding a mammalian homolog of Drosophila Nkd, mNkd, and demonstrated that mNkd interacts directly with Dishevelled. Dishevelled is an intracellular mediator of both the canonical Wn ...[more]