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Catalytic asymmetric aza-Darzens reaction with a vaulted biphenanthrol magnesium phosphate salt.

ABSTRACT: Conditions for a catalytic asymmetric aza-Darzens aziridine synthesis mediated by a vaulted biphenanthrol (VAPOL) magnesium phosphate salt is described. Using simple substrates, this methodology explores the scope and reactivity of a new magnesium catalyst for an aziridination reaction capable of building chirality and complexity simultaneously.

SUBMITTER: Larson SE

PROVIDER: S-EPMC3113529 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature

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Catalytic asymmetric aza-Darzens reaction with a vaulted biphenanthrol magnesium phosphate salt.

Larson Shawn E SE Li Guilong G Rowland Gerald B GB Junge Denise D Huang Rongcai R Woodcock H Lee HL Antilla Jon C JC

Organic letters 20110405 9

Conditions for a catalytic asymmetric aza-Darzens aziridine synthesis mediated by a vaulted biphenanthrol (VAPOL) magnesium phosphate salt is described. Using simple substrates, this methodology explores the scope and reactivity of a new magnesium catalyst for an aziridination reaction capable of building chirality and complexity simultaneously. ...[more]

PMID: 21476598

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