Lack of association of SULT1A1 R213H polymorphism with colorectal cancer: a meta-analysis.

ABSTRACT:

Background

A number of case-control studies were conducted to investigate the association of SULT1A1 R213H polymorphisms with colorectal cancer (CRC) in humans. But the results were not always consistent. We performed a meta-analysis to examine the association between the SULT1A1 R213H polymorphism and CRC.

Methods and findings

Data were collected from the following electronic databases: PubMed, Elsevier Science Direct, Excerpta Medica Database, and Chinese Biomedical Literature Database, with the last report up to September 2010. A total of 12 studies including 3,549 cases and 5,610 controls based on the search criteria were involved in this meta-analysis. Overall, no significant association of this polymorphism with CRC was found (H versus R: OR?=?1.04, 95%CI?=?0.94-1.16, P?=?0.46; HR+HH versus RR: OR?=?1.01, 95%CI?=?0.92-1.11, P?=?0.81; HH versus RR+HR: OR?=?1.01, 95%CI?=?0.74-1.38, P?=?0.95; HH versus RR: OR?=?1.00, 95%CI?=?0.77-1.31, P?=?0.98; HR versus RR: OR?=?1.01, 95%CI?=?0.92-1.11, P?=?0.86). In subgroup analysis, we also did not find any significant association in Cauasians (H versus R: OR?=?1.02, 95%CI?=?0.92-1.15, P?=?0.68; HR+HH versus RR: OR?=?0.99, 95%CI?=?0.91-1.09, P?=?0.90; HH versus RR+HR: OR?=?1.01, 95%CI?=?0.73-1.39, P?=?0.97; HH versus RR: OR?=?0.99, 95%CI?=?0.75-1.31, P?=?0.94; HR versus RR: OR?=?0.99, 95%CI?=?0.90-1.09, P?=?0.85). The results were not materially altered after the studies which did not fulfill Hardy-Weinberg equilibrium were excluded (H versus R: OR?=?1.06, 95%CI?=?0.95-1.19, P?=?0.31; HR+HH versus RR: OR?=?1.03, 95%CI?=?0.93-1.13, P?=?0.56; HH versus RR+HR: OR?=?1.10, 95%CI?=?0.78-1.56, P?=?0.57; HH versus RR: OR?=?1.09, 95%CI?=?0.83-1.44, P?=?0.53; HR versus RR: OR?=?1.02, 95%CI?=?0.92-1.13, P?=?0.75).

Conclusion

This meta-analysis demonstrates that there is no association between the SULT1A1 R213H polymorphism and CRC.

SUBMITTER: Zhang C 

PROVIDER: S-EPMC3113796 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature