Lack of association between insulin receptor substrate2 rs1805097 polymorphism and the risk of colorectal and breast cancer: a meta-analysis.

ABSTRACT:

Background

Insulin receptor substrate-2 (IRS-2), a signaling adaptor protein, was involved in two cancer-related pathways (the phosphatidylinositol 3'-kinase (PI3K) and the extracellular signal-regulated kinase (ERK) pathways). Several studies have evaluated the association between IRS2 rs1805097 (G>A) polymorphisms and the risk of colorectal and breast cancer. However, the results were inconsistent.

Methodology/principal findings

A meta-analysis of seven published case-control studies (4 studies with 4798 cases and 5478 controls for colorectal cancer and 3 studies with 2108 cases and 2507 controls for breast cancer) were conducted to assess the strength of association using crude odd ratios (ORs) with 95% confidence intervals (CIs). For colorectal cancer, no obvious associations were found for all genetic models (homozygote comparison OR?=?0.96, 95%CI 0.85-1.08, Pheterogeneity?=?0.97; heterozygote comparison: OR?=?0.91, 95%CI 0.73-1.13, Pheterogeneity<0.01; dominant model: OR?=?0.92, 95%CI 0.80-1.06, Pheterogeneity?=?0.05; recessive model: OR?=?1.02, 95%CI 0.91-1.14, Pheterogeneity?=?0.60). In the subgroup analysis by ethnicity, control source and consistency of frequency with Hardy-Weinberg equilibrium (HWE), still no significant associations were observed. For breast cancer, also no obvious associations were found for all genetic models (homozygote comparison: OR?=?0.95, 95%CI 0.71-1.26, Pheterogeneity?=?0.10; heterozygote comparison: OR?=?1.00, 95%CI 0.89-1.14, Pheterogeneity?=?0.71; dominant model: OR?=?0.98, 95%CI 0.87-1.10, Pheterogeneity?=?0.55; recessive model: OR?=?0.95, 95%CI 0.72-1.25, Pheterogeneity?=?0.07). We performed subgroup analyses by sample size and did not find an association.

Conclusions

This meta-analysis indicated that IRS2 rs1805097 polymorphism was not associated with colorectal and breast cancer risk.

SUBMITTER: Hu Y 

PROVIDER: S-EPMC3907441 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature