Ontology highlight
ABSTRACT:
SUBMITTER: Maiti D
PROVIDER: S-EPMC3130739 | biostudies-literature | 2009 Dec
REPOSITORIES: biostudies-literature
Journal of the American Chemical Society 20091201 47
O- or N-arylated aminophenol products constitute a common structural motif in various potentially useful therapeutic agents and/or drug candidates. We have developed a complementary set of Cu- and Pd-based catalyst systems for the selective O- and N-arylation of unprotected aminophenols using aryl halides. Selective O-arylation of 3- and 4-aminophenols is achieved with copper-catalyzed methods employing picolinic acid or CyDMEDA, trans-N,N'-dimethyl-1,2-cyclohexanediamine, respectively, as the l ...[more]